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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Sylvie Chastant, Gary England, Oliver Forman, Alexander German, Jan Suchodolski, et al.. Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming. Frontiers in Veterinary Science, 2022, 9, ⟨10.3389/fvets.2022.944821⟩. ⟨hal-03912284⟩
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Romina Via y Rada, Nathalie Daniel, Catherine Archilla, Anne Frambourg, Luc Jouneau, et al.. Identification of the Inner Cell Mass and the Trophectoderm Responses after an In Vitro Exposure to Glucose and Insulin during the Preimplantation Period in the Rabbit Embryo. Cells, 2022, 11 (23), pp. 3766. ⟨10.3390/cells11233766⟩. ⟨hal-03871680⟩
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Marion Bendayan, Emine Sais, Laura Alter, Khadija Fathallah, Monique Jaoul, et al.. For patients with non-obstructive azoospermia, the outcome of testicular sperm extraction correlates with self-esteem, sexual health and the quality of the couple’s relationship. Basic and clinical andrology, 2022, 32 (1), pp.3. ⟨10.1186/s12610-022-00153-z⟩. ⟨hal-03599599⟩
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Miriama Štiavnická, Aurélie Chaulot-Talmon, Jean-Philippe Perrier, Petr Hošek, David Kenny, et al.. Sperm DNA methylation patterns at discrete CpGs and genes involved in embryonic development are related to bull fertility. BMC Genomics, 2022, 23 (1), pp.379. ⟨10.1186/s12864-022-08614-5⟩. ⟨hal-03672214⟩
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Valentin Costes, Aurélie Chaulot-Talmon, Eli Sellem, Jean-Philippe Perrier, Anne Aubert-Frambourg, et al.. Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records. Clinical Epigenetics, 2022, 14 (1), pp.54. ⟨10.1186/s13148-022-01275-x⟩. ⟨hal-03654993⟩
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Emilie Derisoud, Orianne Valais, Luc Jouneau, Alexia Durand, Michèle Dahirel, et al.. Nursing in the periconceptional period alters placental gene expression and subsequent foal growth. 18th European Placenta Group IFPA meeting, European Placenta Group, Nov 2022, Jouy en Josas, France. ⟨hal-03903205⟩
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Laurent Galio, L Bernet, Yoann Rodriguez, Marie-Noëlle Dieudonne, H Pinatel, et al.. Impact of obesity on human endometrial stromal cell decidualization and endometrial control of trophoblast invasion: implication of endometrial extracellular vesicles. 5th meeting of French Society Extracellular Vesicles - October 19 - 21st 2022 Paris, Oct 2022, Paris, France. ⟨hal-03819851⟩
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References
2 121
Open Access
31 %
Keywords
BIOLOGIE DU DEVELOPPEMENT
EMBRYO
Dna methylation
Phénotype
IMAGERIE
Poulain
Epigénétique
Sperm
Bovine
Epigenetics
Blastocyst
Dohad
Development
Oocyte
Spermatogenesis
Male
Souris
Animal modèle
Fertilité
NUCLEAR TRANSFER
Adult
Cheval
Trophoblast
Growth
Ovaire
GENOMIQUE
Développement
Diesel
Expression des gènes
Endomètre
Rabbit
Programmation foetale
Horse
Sexual dimorphism
Embryo development
Nuclear transfer
Fertility
Conceptus
Ruminant
Endometrium
Obesity
Gene expression
Développement embryonnaire
Nutrition
Embryo transfer
Humans
These
Histone
Mouse
Embryo
Sex determination
Embryon
Implantation
Sheep
Lapin
DNA methylation
Goat
Épigénétique
Jument
Dairy cow
Cow
Progesterone
Epigenetic
Placenta
Chorion
Mammary gland
Uterus
Alimentation
DOHaD
Métabolisme
Foetus
Meiosis
Animal model
Gestation
RAT
Bovin
IMMUNOLOGIE
Fetal programming
Ovary
Environment
Somatic cell nuclear transfer
Foxl2
Cattle
GENETIQUE
Female
Méthylation
Mice
Oxidative stress
Reproduction
Animal models
PLACENTA
Transcriptome
Pluripotency
Equine
Methylation
Chromatin
IMAGE
BIOTECHNOLOGIE
Obésité
Pregnancy