Deciphering the Role of CD1e Protein in Mycobacterial Phosphatidyl- myo -inositol Mannosides (PIM) Processing for Presentation by CD1b to T Lymphocytes
Résumé
Background: To become antigenic, mycobacterial hexamannosylated phosphatidyl-myo-inositol (PIM 6) undergo CD1eassisted ␣-mannosidase processing. Results: Measuring membrane-to-membrane PIM transfer, CD1e selectively transferred diacylated PIM species in accordance with the fact that liposome-inserted di-acylated PIM 6 were the only PIM species digested into antigenic molecules by ␣-mannosidase. Conclusion: CD1e assists PIM processing through its lipid transfer protein property. Significance: This study reveals the molecular mechanisms by which CD1e contributes to lipid immunoediting.
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