Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites - Centre de recherche des Cordeliers Accéder directement au contenu
Article Dans Une Revue Aging Année : 2021

Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Romain Daillère
  • Fonction : Auteur

Résumé

The presence of Akkermansia muciniphila (Akk) in the human gut is associated with good health, leanness and fitness. Mouse experimentation has demonstrated positive effects for Akk, which counteracts aging, mediates antiobesity and antidiabetic effects, dampens inflammation and improves anticancer immunosurveillance. Clinical trials have confirmed antidiabetic effects for Akk. Here, we investigated the time-dependent effects of oral administration of Akk (which was live or pasteurized) and other bacteria to mice on the metabolome of the ileum, colon, liver and blood plasma. Metabolomics was performed by a combination of chromatographic and mass spectrometric methods, yielding a total of 1.637.227 measurements. Akk had major effects on metabolism, causing an increase in spermidine and other polyamines in the gut and in the liver. Pasteurized Akk (Akk-past) was more efficient than live Akk in elevating the intestinal concentrations of polyamines, short-chain fatty acids, 2-hydroxybutyrate, as well multiple bile acids, which also increased in the circulation. All these metabolites have previously been associated with human health, providing a biochemical basis for the beneficial effects of Akk.
Fichier principal
Vignette du fichier
aging-v13i5-202739.pdf (5.41 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03195909 , version 1 (12-04-2021)

Identifiants

Citer

Claudia Grajeda-Iglesias, Sylvère Durand, Romain Daillère, Kristina Iribarren, Fabien Lemaitre, et al.. Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites. Aging, 2021, 13 (5), pp.6375-6405. ⟨10.18632/aging.202739⟩. ⟨hal-03195909⟩
117 Consultations
334 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More