Skip to Main content Skip to Navigation
New interface
Theses

Etude du rôle des monocytes dans la pathogénèse du diabète et de ses complications

Abstract : Introduction : Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular(CV) events and severe forms of COVID19. T2DM, atherosclerosis and COVID-19 have pathogenesis related to a pathological inflammatory state. Monocytes (Mono) have both pro- and anti-inflammatory capacities, they are also able to infiltrate tissues and to differentiate into macrophages. We are testing the hypothesis that mono could be associated with the onset of diabetes, atherosclerosis and severe COVID19. Methods : The Mono (totals and subtypes) of a T2DM cohort were quantified (by immunophenotyping (IP)), their correlations with clinicobiological and CV data were studied. The gestational diabetes model was used to assess monocytic changes between normoglycemia (NG), pre-diabetes (PrDt) and T2DM. The relationship between lipidomas and the characteristics of Monos has been studied. Mono from patients hospitalized for severe COVID19 were caracterised by IP and then compared between T2DM and healthy. Results : In the T2D population, the Mono count is associated with sex, smoking, serum creatinine and RCV. Only classical Monos (MC) are associated with the RCV. The percentage of MC increases between NG, PrDt and DT2 but no relation was identified with the lipidomic changes. T2D / COVID19 patients had less mono (decrease in CD) compared to non-T2D / COVID19, but larger ones. Conclusion : Due to their distributional modifications, Mono appears to be associated with the pathogenesis of T2DM and its complications. However, their exact roles remain to be explored.
Complete list of metadata

https://theses.hal.science/tel-03787895
Contributor : ABES STAR :  Contact
Submitted on : Monday, September 26, 2022 - 9:46:06 AM
Last modification on : Tuesday, October 18, 2022 - 4:31:21 AM

File

JULLA_Jean_Baptiste_2021.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-03787895, version 1

Citation

Jean-Baptiste Julla. Etude du rôle des monocytes dans la pathogénèse du diabète et de ses complications. Endocrinologie et métabolisme. Sorbonne Université, 2021. Français. ⟨NNT : 2021SORUS236⟩. ⟨tel-03787895⟩

Share

Metrics

Record views

21

Files downloads

0