Skip to Main content Skip to Navigation
Theses

Exploration biologique de la progression du cancer du rein à haut risque : analyse ancillaire de la cohorte française de l’essai S-TRAC

Abstract : Abstract : Objective: We aimed to explore biological predictive factors of progression after surgery in non-metastatic RCC using the collected tumors in the French cohort of the randomized S-TRAC trial patients. Patients and methods We analyzed the tumors of the French cohort of STRAC that included 44 cases of ccRCC that were collected from 6 centers. The main objective was to explore biological predictive factors of progression (defined as PFS) to sunitinib. Aboard spectrum analysis including immunohistochemistry, FISH, CGH-Array, Transcriptomic analyses were performed on the tumors. Results : Analysis of vascular density showed type 1 vascular stroma corresponding to high vascular density was associated with progression (p<0.034). Loss of PBRM1 (Poly bromo-1) expression showed a distinct profile: a highly histopathological aggressive tumor with a marked angiogenic profile (VEGF over expression and immature vascular stroma type 2), no PD1 or PDL1 expression and WT status of the VHL gene. There were 27 chromosome regions gained in patients with progression (on chromosomes 7 and 16, and to a lesser extent 8, 12, 17, 17, 19, 20 corresponding to 605 associated genes) and 10 regions lost in these same patients on chromosomes 8 and 9, and to a lesser extent 2 and 21 corresponding to 25 associated genes. Conclusion : We found that a angiogenic phenotype defined by a high vascular density with a vascular type 2 stroma was a predictive factor of sunitinib resistance. Regardless of adjuvant treatment, chromosomal gains and losses and genomic alterations including PBRM1 loss were associated with worse outcomes.
Document type :
Theses
Complete list of metadata

https://tel.archives-ouvertes.fr/tel-03283058
Contributor : Abes Star :  Contact
Submitted on : Friday, July 9, 2021 - 4:05:09 PM
Last modification on : Wednesday, October 20, 2021 - 3:19:25 AM
Long-term archiving on: : Sunday, October 10, 2021 - 7:57:00 PM

File

OUZAID_Idir.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-03283058, version 1

Citation

Idir Ouzaid. Exploration biologique de la progression du cancer du rein à haut risque : analyse ancillaire de la cohorte française de l’essai S-TRAC. Médecine humaine et pathologie. Université Rennes 1, 2021. Français. ⟨NNT : 2021REN1B006⟩. ⟨tel-03283058⟩

Share

Metrics

Record views

109

Files downloads

185