Synthesis and crystal structure of 3-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole - Université de Bordeaux Accéder directement au contenu
Article Dans Une Revue Structural Chemistry & Crystallography Communication Année : 2016

Synthesis and crystal structure of 3-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole

Résumé

The X-ray crystal structure of 3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol- 1-yl)piperidin-1-yl)benzyl]}-2-phenylindole, a compound that showed high cytotoxic potential against various leukemia cell lines, was established. The 3D spatial determination confirmed the structure in the solid state. It crystallizes in the triclinic space group P-1 with cell parameters a=9.572(7) Å, b=11.091(2) Å, c=15.976(4) Å, α=92.53(2), β=105.45(3), γ=94.65(3), V=1625.6(13) Å3 and Z=2. The crystal structure was refined to final values of R1=0.0638 and wR2=0.1800. The crystal packing is controlled by intermolecular hydrogen bonding and C-H π interactions. In addition, these new data could be further used to clarify the mechanism of action, implicating the antiproliferative effect of this new synthetic indole derivative on human leukemic cells.
Fichier principal
Vignette du fichier
2016-177 (1).pdf (517.14 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-01432803 , version 1 (20-01-2021)

Identifiants

Citer

Jean Guillon, Marian Vincenzi, Noël Pinaud, Luisa Ronga, Filomena Rossi, et al.. Synthesis and crystal structure of 3-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole. Structural Chemistry & Crystallography Communication, 2016, 2 (1), pp.18. ⟨10.21767/2470-9905.100018⟩. ⟨hal-01432803⟩
157 Consultations
27 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More