Biphasic Chemistry and The Solvent Case
Résumé
This chapter focuses on the field of fluorous chemistry with a broad synthetic focus, i.e. the methodologies developed to facilitate the recycling of catalysts and the purification of reaction products. The principle of fluorous chemistry consists of increasing the affinity of catalysts, reagents or substrates for liquid or solid perfluorinated phases, i.e. increasing their fluorophilicity. In fluorous chemistry, the physicochemical properties of molecules whose affinity for fluorous phases will be increased by the presence of mixed alkylperfluoroalkyl chains, known as fluorous tags (F-tags), are used. The general principle of light fluorous synthesis is to use, in a synthesis, a substrate or reagent modified by a single F-tag. For catalysis applications, fluorous biphasic catalysis is the technique of choice for highly efficient catalyst recycling and has a high potential for industrial applicability. For synthesis applications, light fluorous techniques are particularly well suited to the preparation of compound libraries via automated parallel syntheses.
Origine : Fichiers produits par l'(les) auteur(s)