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Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

Ilaria Silvestri Haining Lyu Francesca Fata Giovanna Boumis 1 Adriana Miele 2 Matteo Ardini Rodolfo Ippoliti 3 Andrea Bellelli 1 Ajit Jadhav Wendy Lea Anton Simeonov Qing Cheng 4 Elias Arnér Gregory Thatcher Pavel Petukhov David R. Williams 5 Francesco Angelucci 1 
1 Department of Biochemical Sciences "Rossi Fanelli"
2 Program in Gene Function and Expression
3 Dipartimento di Biologia di Base ed Applicata
4 Civil Aviation University of China (CHINA)
5 Department of Radiology
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https://hal-udl.archives-ouvertes.fr/hal-02109710
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Submitted on : Thursday, May 16, 2019 - 5:03:38 PM
Last modification on : Thursday, January 6, 2022 - 5:30:02 PM

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Ilaria Silvestri, Haining Lyu, Francesca Fata, Giovanna Boumis, Adriana Miele, et al.. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry. ACS Chemical Biology, American Chemical Society, 2018, 13 (8), pp.2190-2202. ⟨10.1021/acschembio.8b00349⟩. ⟨hal-02109710⟩

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