Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

Ilaria Silvestri , Haining Lyu , Francesca Fata , Giovanna Boumis (1) , Adriana Miele (2) , Matteo Ardini , Rodolfo Ippoliti (3) , Andrea Bellelli (1) , Ajit Jadhav , Wendy Lea , Anton Simeonov , Qing Cheng (4) , Elias Arnér , Gregory Thatcher , Pavel Petukhov , David R. Williams (5) , Francesco Angelucci (1)

1 Department of Biochemical Sciences "Rossi Fanelli"
2 Program in Gene Function and Expression
3 Dipartimento di Biologia di Base ed Applicata
4 Civil Aviation University of China (CHINA)
5 Department of Radiology

Domains: Biochemistry [q-bio.BM]

Ilaria Silvestri, Haining Lyu, Francesca Fata, Giovanna Boumis, Adriana Miele, et al.. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry. ACS Chemical Biology, 2018, 13 (8), pp.2190-2202. ⟨10.1021/acschembio.8b00349⟩. ⟨hal-02109710⟩