Skip to Main content Skip to Navigation
Journal articles

MatrixDB: integration of new data with a focus on glycosaminoglycan interactions

Olivier Clerc 1 Madeline Deniaud 1, 2 Sylvain Vallet 1 Alexandra Naba 3 Alain Rivet 4 Serge Pérez 4 Nicolas Thierry-Mieg 2 Sylvie Ricard-Blum 1
1 ASPE - Assemblages Supramoléculaires Péricellulaires et Extracellulaires
ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
2 TIMC-IMAG-BCM - Biologie Computationnelle et Mathématique
TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
Abstract : MatrixDB (http://matrixdb.univ-lyon1.fr/) is an interaction database focused on biomolecular interactions established by extracellular matrix (ECM) proteins and glycosaminoglycans (GAGs). It is an active member of the International Molecular Exchange (IMEx) consortium (https://www. imexconsortium.org/). It has adopted the HUPO Proteomics Standards Initiative standards for annotating and exchanging interaction data, either at the MIMIx (The Minimum Information about a Molecular Interaction eXperiment) or IMEx level. The following items related to GAGs have been added in the updated version of MatrixDB: (i) cross-references of GAG sequences to the GlyTouCan database, (ii) representation of GAG sequences in different formats (IUPAC and GlycoCT) and as SNFG (Symbol Nomenclature For Glycans) images and (iii) the GAG Builder online tool to build 3D models of GAG sequences from GlycoCT codes. The database schema has been improved to represent n-ary experiments. Gene expression data, imported from Expression Atlas (https://www.ebi.ac.uk/gxa/home), quantitative ECM proteomic datasets (http://matrisomeproject. mit.edu/ecm-atlas), and a new visualization tool of the 3D structures of biomolecules, based on the PDB Component Library and LiteMol, have also been added. A new advanced query interface now allows users to mine MatrixDB data using combinations of criteria, in order to build specific interaction networks related to diseases, biological processes, molecular functions or publications.
Document type :
Journal articles
Complete list of metadata

https://hal-udl.archives-ouvertes.fr/hal-02109904
Contributor : Umr5246 Icbms <>
Submitted on : Tuesday, December 1, 2020 - 2:13:19 PM
Last modification on : Friday, June 25, 2021 - 7:38:02 PM
Long-term archiving on: : Tuesday, March 2, 2021 - 7:23:02 PM

File

gky1035.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Olivier Clerc, Madeline Deniaud, Sylvain Vallet, Alexandra Naba, Alain Rivet, et al.. MatrixDB: integration of new data with a focus on glycosaminoglycan interactions. Nucleic Acids Research, Oxford University Press, 2019, 47 (D1), pp.D376-D381. ⟨10.1093/nar/gky1035⟩. ⟨hal-02109904⟩

Share

Metrics

Record views

526

Files downloads

154