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Journal articles
Pentavalent pillar[5]arene-based glycoclusters and their multivalent binding to pathogenic bacterial lectins
Abstract : Anti-adhesive glycoclusters offer potential as therapeutic alternatives to classical antibiotics in treating infections. Pillar[5]arenes functionalised with either five galactose or five fucose residues were readily prepared using CuAAC reactions and evaluated for their binding to three therapeutically relevant bacterial lectins: LecA and Lec B from Pseudomonas aeuruginosa and BambL from Burkholderia ambifaria. Steric interactions were demonstrated to be a key factor in achieving good binding to LecA with more flexible galactose glycoclusters showing enhanced activity. In contrast binding to the fucose-selective lectins confirmed the importance of topology of the glycoclusters for activity with the pillar[5]arene ligand proving a selective ligand for BambL.
https://hal-udl.archives-ouvertes.fr/hal-02123866
Contributor : Umr5246 Icbms <>
Submitted on : Thursday, May 9, 2019 - 9:52:00 AM
Last modification on : Friday, November 6, 2020 - 4:18:49 AM
Contributor : Umr5246 Icbms <>
Submitted on : Thursday, May 9, 2019 - 9:52:00 AM
Last modification on : Friday, November 6, 2020 - 4:18:49 AM
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