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Journal articles
3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors
Abstract : Glycogen phosporylase (GP) is a promising target for the control of glycaemia. The design of inhibitors binding at the catalytic site has been accomplished through various families of glucose-based derivatives such as oxadiazoles. Further elaboration of the oxadiazole aromatic aglycon moiety is now reported with 3-glucosyl-5-amino-1,2,4-oxadiazoles synthesized by condensation of a C-glucosyl amidoxime with N,N’-dialkylcarbodiimides or Vilsmeier salts. The 5-amino group introduced on the oxadiazole scaffold was expected to provide better inhibition of GP through potential additional interactions with the enzyme’s catalytic site; however, no inhibition was observed at 625 µM.
https://hal-udl.archives-ouvertes.fr/hal-02123939
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Submitted on : Thursday, May 9, 2019 - 10:47:23 AM
Last modification on : Tuesday, December 7, 2021 - 12:30:06 PM
Contributor : Umr5246 Icbms Connect in order to contact the contributor
Submitted on : Thursday, May 9, 2019 - 10:47:23 AM
Last modification on : Tuesday, December 7, 2021 - 12:30:06 PM
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