α-Methylation of ketones with methanol catalyzed by Ni/SiO2-Al2O3

Aubin Charvieux (1) , Nicolas Duguet (1) , Estelle Metay (1)

1 CASYEN - Catalyse Synthèse et Environnement

α-Methylation of ketones with methanol catalyzed by a cheap and easy to handle Ni/SiO2-Al2O3 was explored. After optimization of the reaction between propiophenone and methanol, the desired product was obtained in 95 % isolated yield. A wide range of ketones was methylated under the optimized conditions (16 examples). This procedure was extended to a three-component cross-benzylation-methylation of acetophenone.

Domains: Organic chemistry; Catalysis

Aubin Charvieux, Nicolas Duguet, Estelle Metay. α-Methylation of ketones with methanol catalyzed by Ni/SiO2-Al2O3. European Journal of Organic Chemistry, 2019, 2019 (22), pp.3694-3698. ⟨10.1002/ejoc.201900602⟩. ⟨hal-02128693⟩