Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial

Issaka Sagara (1) , Abdoul Habib Beavogui (2) , Issaka Zongo , Issiaka Soulama (3) , Isabelle Borghini-Fuhrer , Bakary Fofana (4) , Aliou Traore , Nouhoum Diallo , Hamadoun Diakite , Amadou Togo (5) , Sekou Koumare , Mohamed Keita , Daouda Camara , Anyirékun Somé , Aboubacar Coulibaly , Oumar Traoré (6) , Souleymane Dama (7) , Siaka Goïta (8) , Moussa Djimde (7) , Amadou Bamadio (7) , Niawanlou Dara (7) , Hamma Maiga (7) , Bouran Sidibe , Francois Dao , Moctar Coulibaly , Mohamed Lamine Alhousseini (7) , Hamidou Niangaly (9) , Boubou Sangare , Modibo Diarra , Samba Coumare , Moïse Kabore , San Maurice Ouattara , Aissata Barry , Désiré Kargougou , Amidou Diarra (3) , Noelie Henry , Harouna Soré , Edith Bougouma (3) , Ismaila Thera , Yves Compaore , Colin Sutherland (10) , Malick Minkael Sylla , Frederic Nikiema , Mamadou Saliou Diallo , Alassane Dicko (1) , Stéphane Picot (11) , Steffen Borrmann (12) , Stephan Duparc , Robert Miller (13) , Ogobara Doumbo (7) , Jangsik Shin , José Pedro Gil (14) , Anders Bjorkman (15) , Jean-Bosco Ouédraogo (16) , Sodiomon B Sirima (3) , Abdoulaye Djimde (17)

1 Department of Epidemiology of Parasitic Diseases
2 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
3 CNRFP - Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso]
4 USTTB - Université des Sciences, des Techniques et des Technologies de Bamako
5 Université Bordeaux Segalen - Bordeaux 2
6 Département de mathématiques
7 Malaria Research and Training Center [Bamako, Mali]
8 Département d'Epidémiologie des Affections parasitaires, Malaria Research and training center Université de Bamako, Mali
9 MRTC - Malaria Research and Training Center
10 LSHTM - London School of Hygiene and Tropical Medicine
11 Radicaux Libres, Substrats Énergétiques et Physiopathologie Cérébrale
12 DZIF - German Center for Infection Research - partner site Hannover-Braunschweig
13 Royal Free and University College Medical School
14 Uppsala University
15 Karolinska Institutet [Stockholm, Sweden]
16 INSSA - Institut de Recherche en Sciences de la Santé Bobo Dioulasso
17 DEAP - Département d'épidémiologie des affections parasitaires

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology

Issaka Sagara, Abdoul Habib Beavogui, Issaka Zongo, Issiaka Soulama, Isabelle Borghini-Fuhrer, et al.. Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial. The Lancet, 2018, 391 (10128), pp.1378-1390. ⟨10.1016/S0140-6736(18)30291-5⟩. ⟨hal-02136477⟩