 |
Journal articles
Biological Evaluation and Docking Studies of New Carbamate, Thiocarbamate, and Hydrazide Analogues of Acyl Homoserine Lactones as Vibrio fischeri-Quorum Sensing Modulators
Abstract : Phosphodiesters of glucose-2-phosphate (G2P) are found only in few natural compounds such as agrocinopine D and agrocin 84. Agrocinopine D is a G2P phosphodiester produced by plants infected by Agrobacterium fabrum C58 and recognized by the bacterial periplasmic binding protein AccA for being transported into the bacteria before cleavage by the phosphodiesterase AccF, releasing G2P, which promotes virulence by binding the repressor protein AccR. The G2P amide agrocin 84 is a natural antibiotic produced by the non-pathogenic Agrobacterium radiobacter K84 strain used as a biocontrol agent by competing with Agrobacterium fabrum C58. G2P esters are also found in irregular glycogen structures. The rare glucopyranosyl-2-phophoryl moiety found in agrocin 84 is the key structural signature enabling its action as a natural antibiotic. Likewise, G2P and G2P esters can also dupe the Agrobacterium agrocinopine catabolism cascade. Such observations illustrate the importance of G2P esters on which we have recently focused our interest. After a brief review of the reported phosphorylation coupling methods and the choice of carbohydrate building blocks used in G2P chemistry, a flexible access to glucose-2-phosphate esters using the phosphoramidite route is proposed.
Cited literature [46 references]
https://hal-udl.archives-ouvertes.fr/hal-02883805
Contributor : Umr5246 Icbms <>
Submitted on : Monday, June 29, 2020 - 2:58:46 PM
Last modification on : Friday, June 25, 2021 - 7:38:02 PM
Contributor : Umr5246 Icbms <>
Submitted on : Monday, June 29, 2020 - 2:58:46 PM
Last modification on : Friday, June 25, 2021 - 7:38:02 PM
File
biomolecules-10-00455-v2.pdf
Publisher files allowed on an open archive