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Potentiel du couplage de la chromatographie en phase liquide bidimensionnelle avec l’ICP-MS/MS pour l’analyse de matrices organiques complexes

Abstract : Two-dimensional liquid chromatography coupled with a specific detection such as inductively coupled plasma mass spectrometry (LCxLC-ICP-MS/MS) proves to be a relevant technique for the characterization of petroleum complex matrices. Such coupling makes it possible to consider the speciation of sulfur or metal contaminants (vanadium and nickel). Firstly, the evaluation and the comparison of several sample introduction systems was performed, with regard to the dispersion induced in the system, in order to keep a high efficiency from the LCxLC system. The second part of the instrumental development concern the optimization of both dimensions. The choice of the different retention mechanisms is essential given the complexity of the samples (polarity, solubility, molecular weight...). Additionally, the introduction of organic matrices in the plasma remains a real challenge which could be the cause of many instrumental and analytical issue. Finally, once the off-line SECxRPLC-ICP-MS/MS method was developed, it was applied to different samples showing how it can be considered as an interesting tool to explain the behavior of matrices within the refining units, through the comparison of 2D-contour plots
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Marie Bernardin. Potentiel du couplage de la chromatographie en phase liquide bidimensionnelle avec l’ICP-MS/MS pour l’analyse de matrices organiques complexes. Chimie analytique. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1220⟩. ⟨tel-02447668⟩

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