The vermiform appendix impacts the risk of developing Parkinson’s disease

Bryan Killinger (1) , Zachary Madaj (2, 1) , Jacek Sikora (3, 4) , Nolwen L. Rey (5, 1) , Alec Haas (1) , Yamini Vepa (1) , Daniel Lindqvist (6) , Honglei Chen (7, 8) , Paul Thomas (9, 4) , Patrik Brundin (1) , Lena Brundin (10, 1) , Viviane Labrie (1)

1 Van Andel Institute [Grand Rapids]
2 Bioinformatics and Biostatistics Core, Van Andel Research Institute
3 Laboratory of Mass Spectrometry Institute of Biochemistry and Biophysics
4 Northwestern University [Evanston]
5 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
6 Department of Clinical Sciences [Lund]
7 AAHL - Australian Animal Health
8 College of Human Medicine, Michigan State University
9 Dstl - Defence Science and Technology Laboratory
10 Center for Neurodegenerative Science, Van Andel Research Institute

The human appendix is a reservoir for α-synuclein aggregates and its removal may reduce the risk of Parkinson’s disease.

Domains: Neurons and Cognition [q-bio.NC]

Bryan Killinger, Zachary Madaj, Jacek Sikora, Nolwen L. Rey, Alec Haas, et al.. The vermiform appendix impacts the risk of developing Parkinson’s disease. Science Translational Medicine, 2018, 10 (465), ⟨10.1126/scitranslmed.aar5280⟩. ⟨hal-04247698⟩