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Polymethylmethacrylate derivatives Eudragit E100 and L100: Interactions and complexation with surfactants

Abstract : Precipitation or coprecipitation of polyelectrolytes has been largely investigated. However, the precipitation of polyelectrolytes via addition of charged and non-charged surfactants has not been systematically studied and reported. Consequently, the aim of this work is to investigate the effect of different surfactants (anionic, cationic, non-charged and zwitterionic) on the precipitation of cationic and anionic polymethyl methacrylate polymers (Eudragit). The surfactants effect has been investigated as a function of their concentration. Special attention has been dedicated to the CMC range and to the colloidal characterization of the formed dispersions. Moreover, the effect of salt (NaCl) and pH was also addressed. It is pointed out that non-ionic and zwitterionic surfactants do not interact with charged Eudragit E100 and L100. For oppositely charged Eudragit E100/SDS and Eudragit L100/CTAB, precipitation occurs, and the obtained dispersions have been characterized in terms of particle size distribution and zeta potential. It was established that the binding of SDS molecules to Eudragit E100 polymer chains is made through the negative charges of the surfactant heads under the CMC value whereas binding of CTAB to Eudragit L100 chains is made at a CTAB concentration 5 times above its CMC. For Eudragit E100/SDS system, a more acidic medium induces aggregation. A same result was observed for the Eudragit L100/CTAB at a more basic pH. Moreover, it was observed that increasing salt concentration (higher than 100 mM) led to aggregation as generally observed for polycations/anionic surfactant systems.
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Contributor : Noureddine Lebaz <>
Submitted on : Friday, December 11, 2020 - 1:01:33 PM
Last modification on : Monday, January 4, 2021 - 2:38:01 PM


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Fabrice Ofridam, Noureddine Lebaz, E. Gagnière, Denis Mangin, Abdelhamid Elaïssari. Polymethylmethacrylate derivatives Eudragit E100 and L100: Interactions and complexation with surfactants. Polymers for Advanced Technologies, Wiley, 2021, 32, pp.379-390. ⟨10.1002/pat.5093⟩. ⟨hal-02941359⟩



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