Modified Julia Olefination on Sugar-Derived Lactones: Synthesis of Difluoro- exo -glycals
Abstract
We report the preparation of difluoro-exo-glycals by gem-difluoroolefination of benzylated sugar-derived lactones using a modified Julia reaction. The addition is highly stereoselective, and the Smiles-rearrangement–elimination sequence can be carried out under microwave irradiation.