α-Methylation of ketones with methanol catalyzed by Ni/SiO2-Al2O3 - Archive ouverte HAL Access content directly
Journal Articles European Journal of Organic Chemistry Year : 2019

α-Methylation of ketones with methanol catalyzed by Ni/SiO2-Al2O3

(1) , (1) , (1)
1

Abstract

α-Methylation of ketones with methanol catalyzed by a cheap and easy to handle Ni/SiO2-Al2O3 was explored. After optimization of the reaction between propiophenone and methanol, the desired product was obtained in 95 % isolated yield. A wide range of ketones was methylated under the optimized conditions (16 examples). This procedure was extended to a three-component cross-benzylation-methylation of acetophenone.
Fichier principal
Vignette du fichier
Eur_J_Org_Chem_2019_3694-3698.pdf (1.53 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-02128693 , version 1 (03-06-2021)

Identifiers

Cite

Aubin Charvieux, Nicolas Duguet, Estelle Metay. α-Methylation of ketones with methanol catalyzed by Ni/SiO2-Al2O3. European Journal of Organic Chemistry, 2019, 2019 (22), pp.3694-3698. ⟨10.1002/ejoc.201900602⟩. ⟨hal-02128693⟩
38 View
69 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More