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Abstract : α-Methylation of ketones with methanol catalyzed by a cheap and easy to handle Ni/SiO2-Al2O3 was explored. After optimization of the reaction between propiophenone and methanol, the desired product was obtained in 95 % isolated yield. A wide range of ketones was methylated under the optimized conditions (16 examples). This procedure was extended to a three-component cross-benzylation-methylation of acetophenone.
https://hal-udl.archives-ouvertes.fr/hal-02128693 Contributor : UMR5246 ICBMSConnect in order to contact the contributor Submitted on : Thursday, June 3, 2021 - 3:25:13 PM Last modification on : Sunday, June 26, 2022 - 3:09:02 AM Long-term archiving on: : Saturday, September 4, 2021 - 6:55:46 PM
Aubin Charvieux, Nicolas Duguet, Estelle Metay. α-Methylation of ketones with methanol catalyzed by Ni/SiO2-Al2O3. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 2019 (22), pp.3694-3698. ⟨10.1002/ejoc.201900602⟩. ⟨hal-02128693⟩