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α-Methylation of ketones with methanol catalyzed by Ni/SiO2-Al2O3

Aubin Charvieux 1 Nicolas Duguet 1 Estelle Metay 1
1 CASYEN - Catalyse Synthèse et Environnement
ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
Abstract : α-Methylation of ketones with methanol catalyzed by a cheap and easy to handle Ni/SiO2-Al2O3 was explored. After optimization of the reaction between propiophenone and methanol, the desired product was obtained in 95 % isolated yield. A wide range of ketones was methylated under the optimized conditions (16 examples). This procedure was extended to a three-component cross-benzylation-methylation of acetophenone.
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Aubin Charvieux, Nicolas Duguet, Estelle Metay. α-Methylation of ketones with methanol catalyzed by Ni/SiO2-Al2O3. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 2019 (22), pp.3694-3698. ⟨10.1002/ejoc.201900602⟩. ⟨hal-02128693⟩

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